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Abstract
Antioxidant agents play a pivotal role in the treatment of diseases and wound healing. The biennial plant, Launaea sarmentosa (Willd.) Sch. Bip. ex Kuntze, from the Asteraceae, possesses essential phenolic compounds such as flavonoids and polyphenols. Historically, this plant has demonstrated significant healing properties for various wounds, including those caused by itching, infection, blisters, and conditions like herpes zoster. Given its potential therapeutic benefits, this study sought to evaluate the crude extracts of L. sarmentosa for their antioxidant, antibacterial, and anti-inflammatory properties. Leaves harvested during both rainy and summer seasons from Phuket Province, Thailand were subjected to extraction using five solvents: hexane, ethyl acetate, ethanol, methanol, and distilled water. Total phenolics analysis indicated that the distilled water solvent yielded the highest concentrations, with values of 55.689+0.452 mg GAE/g and 95.740+0.484 mg GAE/g dry weight for the rainy and summer samples, respectively. Similarly, total flavonoid contents were highest in these extracts, with values of 205.566+0.782 mg QUE/g and 266.550+4.059 mg QUE/g dry weight. Antioxidant activities were evaluated using the DPPH scavenging test, with the methanol extracts displaying the most potent activity, possessing IC50 values of 0.057+1.355 mg/mL (rainy season) and 0.050+3.044 mg/mL (summer season). These results underscore the potential of L. sarmentosa as a key ingredient for the formulation of hydrogel wound healing patches.
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References
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